ABSTRACT
A nova variante da Doença de Creutzfeld-Jakob, cuja origem é atribuida à ingestão de produtos de origem animal - especialmente bovino - contendo a proteína priônica, traz novos desafios a cientistas e profissionais de saúde pública.
Subject(s)
Encephalopathy, Bovine Spongiform/diagnosis , Encephalopathy, Bovine Spongiform/pathology , Encephalopathy, Bovine Spongiform/transmissionSubject(s)
Humans , Animals , Cattle , Encephalopathy, Bovine Spongiform/prevention & control , Argentina , Chickens , Encephalopathy, Bovine Spongiform/epidemiology , Encephalopathy, Bovine Spongiform/transmission , Creutzfeldt-Jakob Syndrome/transmission , United Kingdom , United States , United States Department of Agriculture/standardsSubject(s)
Animals , Brain/metabolism , Creutzfeldt-Jakob Syndrome/epidemiology , Disease Transmission, Infectious/prevention & control , Encephalopathy, Bovine Spongiform/transmission , Genetic Predisposition to Disease/genetics , History, 18th Century , History, 19th Century , History, 20th Century , Humans , Kuru/history , PrPC Proteins/genetics , Prion Diseases/epidemiology , Scrapie/historySubject(s)
Humans , Animals , Creutzfeldt-Jakob Syndrome/etiology , Creutzfeldt-Jakob Syndrome/transmission , Encephalopathy, Bovine Spongiform/etiology , Encephalopathy, Bovine Spongiform/transmission , Prion Diseases/etiology , Prion Diseases/transmission , Kuru/etiology , Kuru/transmission , Prions , PrPC Proteins , Scrapie/etiology , Scrapie/transmission , SheepABSTRACT
A new variant of Creutzfeldt-Jakob Disease [V-CJD] has been recently described. V-CJD is charaderized by early onset, atypical clinical presentation and the presence of multiple plaques that consist of prion protein in the affected regions of the brain. A link between V-CJD and bovine spongiform encephalopathy [BSE] has been suspected. The currently available data, analyzed in this review, suggest hat the likelihood of BSE transmission to humans is very low. However, such a possibility cannot be excluded unequivocally and additional studies are required